Heap o' Links Thu Oct 29, 2026

Mgoes (bio/acc @m_goes_distance
this might be my last normal tweet before biotech goes vertical

i'm not a whistleblower. I don't work at Lilly, Novo or any of the big labs

but there is a massive shift happening in human biology right now.

it's sitting in press releases and almost nobody reads them

the last 6 months alone:

- a once-daily pill roughly doubled median survival in metastatic pancreatic cancer (13.2 vs 6.6 months)
- a one-time gene editing infusion cut hereditary angioedema attacks 87%, and 62% of patients stayed attack-free and off all other prevention for 6 months
- a one-time gene edit for cholesterol dropped LDL up to 62%, and it held for over a year
- a personalized mrna vaccine beat keytruda alone in a 1,137 patient melanoma phase 3
- retatrutide hit ~28% weight loss in a phase 3
- an ai-designed drug entered phase 3
- a pill that regrows hair passed its second phase 3
- an immunotherapy that could let some rectal cancer patients skip surgery, chemo and radiation just got fda approved
- a man lived 271 days off dialysis on a pig kidney
- human cells were caught passing chromosome-sized chunks of DNA to their neighbors, and it changes how the neighbors behave

we are on the verge of an era where the human body is a software problem and the update cycle gets shorter everyday

stick around, it's going to get weird

bio/acc